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predicTox homepage. A screenshot of the homepage, which provides searchable... Open Access
Published: 02 February 2026
Figure 1.
predicTox homepage. A screenshot of the homepage, which provides searchable DrugTox summary cards and gene summary Cards. The homepage also provides clickable links to various pages that list data sets and other downloadable materials.
Journal Article
predicTox: an integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugs Open Access
Database, Volume 2026, 2026, baag003, https://doi.org/10.1093/database/baag003
Published: 02 February 2026
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DrugTox summary card for pazopanib. DrugTox summary cards provide a concise... Open Access
Published: 02 February 2026
Figure 2.
DrugTox summary card for pazopanib. DrugTox summary cards provide a concise summary of the drug class, its cardiotoxic potential from FAERS ranking and literature summary, ranked list of genes and pathways affected by the drug in the indicated human iPSC cardiomyocyte lines and potential genomic var
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Pathways predicted to be associated with TKI-induced cardiotoxicity. (A) Th... Open Access
Published: 02 February 2026
Figure 3.
Pathways predicted to be associated with TKI-induced cardiotoxicity. (A) The top 25 up- and downregulated pathways that were predicted to be associated with TKI-induced cardiotoxicity can be queried on the ‘Drug-induced pathways associated with cardiotoxicity’ page. This page can be opened by select
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Genomic variants that are potentially associated with a drug’s cardiotoxici... Open Access
Published: 02 February 2026
Figure 4.
Genomic variants that are potentially associated with a drug’s cardiotoxicity by interfering with the drug’s PD or PK. Note that some genomic variants can map to multiple genes. This page can be opened by selecting the ‘Bulk transcriptomic datasets—Metadata’ button on the main page, and then ‘Predic
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Steps of DUF data curation. (i) Extract and download a list of PFAM ID/DUF ... Open Access
Published: 23 January 2026
Figure 2
Steps of DUF data curation. (i) Extract and download a list of PFAM ID/DUF ID/SCOPe ID using search criteria, (a) pathway names and (b) catalytic cysteines [ 6, 7 ] (ii) filter the downloaded list using SCOPe superfamily resulting enzyme names from 7 biochemical pathways studied here; (iii) search S
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Depiction of cysteine (Cys22), part of a disulfide bridge (PDB ID:8PCH). Pr... Open Access
Published: 23 January 2026
Figure 3
Depiction of cysteine (Cys 22), part of a disulfide bridge (PDB ID:8PCH). Protein microenvironment (4.5 Å radius) around Cys22 is depicted, in stick representation. The protein background is shown as cartoon representation. The figure was generated using VMD software.
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Confusion matrix to validate the predicted cysteine PTMs (using DeepCys sof... Open Access
Published: 23 January 2026
Figure 4
Confusion matrix to validate the predicted cysteine PTMs (using DeepCys software) with the experimental (PDB header file) observations. The heatmap indicates the range of cysteine numbers.
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Distribution of cysteine protein microenvironments, from DUF proteins, in t... Open Access
Published: 23 January 2026
Figure 5
Distribution of cysteine protein microenvironments, from DUF proteins, in three clusters, buried hydrophobic, buried hydrophilic, and exposed hydrophilic. The X-axis represents the BF; the Y-axis, rHpy; and the Z-axis, populations of cysteine. Three insets show the relative position of the cysteine
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Simple tree representing the species in this study based on taxonomy for vi... Open Access
Published: 23 January 2026
Figure 7
Simple tree representing the species in this study based on taxonomy for virus and archaebacteria. The figure was generated using ITOL version 7.
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Simple tree for disease-causing bacteria, classified according to their tax... Open Access
Published: 23 January 2026
Figure 8
Simple tree for disease-causing bacteria, classified according to their taxonomy. The number of species per genera is shown on the connecting branch. One example per genera is shown for clarity. The figure was generated using ITOL version 7.
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Counts of functional cysteines across twenty different diseases, categorize... Open Access
Published: 23 January 2026
Figure 10
Counts of functional cysteines across twenty different diseases, categorized according to protein microenvironment clusters, (a) DeepCys-structure-based prediction tool and (b) CysDuF database.
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Schematic representation of four cysteine PTMs described in the CysDuF data... Open Access
Published: 23 January 2026
Figure 1
Schematic representation of four cysteine PTMs described in the CysDuF database.
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Schematic representations of Cys-PTMs in different pathways curated from li... Open Access
Published: 23 January 2026
Figure 6
Schematic representations of Cys-PTMs in different pathways curated from literature, (a) ETC, (b) Fe–S cluster biogenesis, (c) glutathione biosynthesis, (d) fatty acid biosynthesis, (e) Kreb’s cycle, (f) pentose phosphate pathways. The amino acids and protein structures were depicted using VMD softw
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Web application for (a) DeepCys—structure-based prediction tool and (b) Cys... Open Access
Published: 23 January 2026
Figure 11
Web application for (a) DeepCys—structure-based prediction tool and (b) CysDUF database.
Journal Article
CysDuF database: annotation and characterization of cysteine residues in domain of unknown function proteins based on cysteine post-translational modifications, their protein microenvironments, biochemical pathways, taxonomy, and diseases Open Access
Database, Volume 2026, 2026, baag002, https://doi.org/10.1093/database/baag002
Published: 23 January 2026
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Schematic representations of Cys-PTMs in different pathways curated from li... Open Access
Published: 23 January 2026
Figure 6
Schematic representations of Cys-PTMs in different pathways curated from literature, (a) ETC, (b) Fe–S cluster biogenesis, (c) glutathione biosynthesis, (d) fatty acid biosynthesis, (e) Kreb’s cycle, (f) pentose phosphate pathways. The amino acids and protein structures were depicted using VMD softw
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Disease-causing bacteria infecting different organs, categories based on an... Open Access
Published: 23 January 2026
Figure 9
Disease-causing bacteria infecting different organs, categories based on anatomy. Counts of cysteine residues present in DUF proteins per disease category are shown.
Journal Article
A comprehensive database for biological data derived from sewage in five European cities Open Access
Database, Volume 2026, 2026, baaf089, https://doi.org/10.1093/database/baaf089
Published: 20 January 2026
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A simplified overview of the database scheme. tables closely related togeth... Open Access
Published: 20 January 2026
Figure 2.
A simplified overview of the database scheme. tables closely related together are coloured according to what kind of information they represent. The ‘meta’ table and the ‘location’ table encompass metainformation. The tables ‘resfinder_gene_abundance’ and ‘resfinder_class_abundance’ joined with deta
